High protein in urine, known as proteinuria, can be caused by various factors, including kidney diseases, infections, diabetes, high blood pressure, certain medications, and physical or emotional stress. Proteinuria occurs when the glomeruli, the tiny filtering units in the kidneys, become damaged or inflamed, leading to increased passage of protein into the urine. Conditions that can contribute to proteinuria include diabetic nephropathy, focal segmental glomerulosclerosis (FSGS), membranous nephropathy, and other glomerular diseases. Additionally, conditions that increase blood pressure or affect kidney function, such as kidney infections or urinary tract obstructions, can result in proteinuria. Certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), can also cause temporary proteinuria. Physical stress, intense exercise, or emotional stress can lead to temporary proteinuria, which typically resolves once the stress is relieved. Identifying the underlying cause of proteinuria is crucial to determine the appropriate treatment and protect kidney function. If proteinuria is persistent or severe, further evaluation and management by a healthcare professional are essential. Regular monitoring of proteinuria through tests like the protein to creatinine ratio (PCR) or albumin-to-creatinine ratio (ACR) can help track kidney health and assess treatment effectiveness. Early detection and intervention are crucial in managing proteinuria and promoting overall kidney health.