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Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is an extremely rare genetic disorder characterized by the progressive replacement of muscles, tendons, and other soft tissues with bone. This abnormal bone growth occurs spontaneously or as a response to injury, leading to joint immobility, limited range of motion, and progressively severe disability. FOP is considered one of the most disabling conditions known to medicine.

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