Plasma Free Metanephrines To Diagnose or Rule Out Rare Tumor PPGL

Plasma Free Metanephrines To Diagnose or Rule Out Rare Tumor PPGL

The Plasma Free Metanephrines Test is a blood test used to detect rare adrenal gland tumors like pheochromocytoma or a paraganglioma (PPGL). It helps diagnose high blood pressure caused by these tumors.

 

Plasma Free Metanephrines Test

Here are the basic details of the Plasma Free Metanephrines Test.

Also Known As Metanephrines Blood Test
Type Diagnostic Blood Test
Purpose Detect Adrenal Tumors Causing High Blood Pressure
Sample Type Plasma
Preparation Medication Review, Dietary Restrictions
Fasting Often Requires
Gender Unisex
Age Group All
Normal Value 7.90 - 88.70 ng/L
Reporting Time A few days
Cost 4500-6000 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

 

Plasma Free Metanephrines Test Means

Plasma Free Metanephrines Test is a blood test used to detect rare adrenal tumors like pheochromocytomas that can lead to high blood pressure.

  • It measures metanephrine and normetanephrine levels, which are breakdown products of catecholamines produced by the adrenal glands.
  • Elevated levels can indicate the presence of these tumors.
  • Proper preparation, including fasting and medication review, is essential for accurate results.
  • This test is crucial for early diagnosis and treatment of these rare tumors, which can have serious health consequences if left untreated.

 

Plasma Free Metanephrines Test Purpose

The purpose of the Plasma Free Metanephrines Test is to:

  • Diagnoses rare adrenal tumors causing high blood pressure.
  • Identifies pheochromocytomas and paragangliomas through metanephrine and normetanephrine levels.
  • Assists in monitoring tumor recurrence after treatment.
  • Useful for individuals with hereditary risk factors or unresponsive hypertension.
  • Ensures timely diagnosis and management of these potentially dangerous conditions.

Plasma Free Metanephrines Test_ Price, Normal Range, Result, Purpose, Meaning and Interpretation - Drlogy Test

 

Plasma Free Metanephrines Test Preparation

Here is the basic preparation for the Plasma Free Metanephrines Test.

 

Before Test

  • Review and discuss medications with the healthcare provider.
  • Follow dietary restrictions, avoiding certain foods, caffeine, and smoking.
  • Minimize emotional and physical stress.

 

During Test

  • Blood sample collected from a vein, typically in the arm.
  • It's recommended to be seated or lying down during collection.
  • Follow any specific instructions provided by the healthcare practitioner.

 

After Test

  • Resume normal activities unless advised otherwise.
  • Await test results, typically available in 1-3 days.
  • Consult with your healthcare provider for result interpretation and further guidance.

 

Plasma Free Metanephrines Test Procedure

Here is the basic Plasma Free Metanephrines Test Procedure.

  • Blood sample drawn from a vein, often in the arm.
  • Typically performed while seated or lying down.
  • Follow specific instructions from the healthcare practitioner.
  • Sample is sent to the lab for analysis.
  • Results are reported to the healthcare provider for interpretation.

 

Plasma Free Metanephrines Test Result

  • Normal levels suggest a lower likelihood of adrenal tumors.
  • Elevated levels indicate potential presence of pheochromocytomas or paragangliomas.
  • Further tests and imaging are needed to locate and assess the tumor.

 

Plasma Free Metanephrines Test Normal Range

Here is the normal range of the Plasma Free Metanephrines Test.

Test Normal Range (ng/L)
Plasma Free Metanephrines 7.90 - 88.70

 

Plasma Free Metanephrines Test Interpretation

Here is the Interpretation of the Plasma Free Metanephrines Test.

Result Interpretation
Normal Unlikely to have adrenal tumors.
High Possible adrenal tumors; further tests and imaging needed.

The Plasma Free Metanephrines Test helps diagnose adrenal tumors causing high blood pressure by measuring hormone levels in the blood.

 

Plasma Free Metanephrines Test High Levels

Here are some possible causes of high Plasma Free Metanephrines levels:

Possible Causes Effects
Pheochromocytomas High blood pressure, headaches, sweating
Paragangliomas Rapid heart rate, palpitations, tremors
Medications, stress, and diet False-positive results, inaccurate test

 

Plasma Free Metanephrines Test Low Levels

Here are some possible causes of Plasma Free Metanephrines levels:

Possible Causes Effects
Rare, usually not assessed No specific effects
Certain medical conditions May be associated with underlying health issues

 

Specimen Requirements For Plasma Free Metanephrines Test

Here are the specimen requirements for the Plasma Free Metanephrines Test.

Specimen

Plasma

Volume

0.6 mL

Container

Lavender-top (EDTA) tube

Collection

Chill lavender tube, invert, centrifuge, transfer plasma, with recumbent patient.

Storage

Refrigerate or freeze.

Sample Stability

Temperature

Period

Room temperature

Unstable

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

 

Plasma Free Metanephrines Test is Safe?

Plasma Free Metanephrines Test is generally safe diagnostic blood test.

  • Minimal risks, such as minor discomfort or bruising at the collection site.
  • Performed by trained healthcare professionals.
  • Important for diagnosing and managing adrenal tumors.
  • Risks associated with the test are minimal compared to its diagnostic benefits.

 

When Do You Get Plasma Free Metanephrines Test Results? 

  • Typically, results available within 1-3 days.
  • Time may vary based on the laboratory and location.
  • Contact healthcare provider for result interpretation.

 

Plasma Free Metanephrines Test Limitation

Here is the basic limitation of Plasma Free Metanephrines Test.

  • False positives are possible, influenced by medications, stress, and diet.
  • The test doesn't provide information on tumor size or location.
  • Results can vary during the day due to fluctuating hormone levels.
  • Limited in distinguishing between benign and malignant tumors.
  • The test may not identify the cause of high blood pressure in all cases.

 

Plasma Free Metanephrines Test Risk Factors

Here are some of the risk factors of the Plasma Free Metanephrines Test.

  • Family history of adrenal tumors can increase the risk.
  • Genetic syndromes like VHL and MEN2 are associated with higher risk.
  • People with underlying hypertension may be more prone.
  • Medications can affect test accuracy, leading to potential risks.
  • Failing to follow preparation instructions can impact the results and risk proper diagnosis.

 

Doctor Recommendations After Plasma Free Metanephrines Test Result

 Here are the Doctor's recommendations or consult a specialist after the Plasma Free Metanephrines Test.

Test Result Doctor to Visit Reason
High Endocrinologist Confirm adrenal tumor, discuss treatment.
Normal Routine follow-up Monitor health, no immediate concerns.
Low Primary care physician Rule out potential underlying issues.

 

Plasma Free Metanephrines Test Price

Here are the estimated Plasma Free Metanephrines Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

4500-6000

New Delhi

4000-6000

Bangalore

4500-6000

Hyderabad

4000-6000

Kolkata

4500-6000

Pune

4000-6000

Lucknow

4500-6000

Noida

4000-6000

Surat

4000-6000

Gurugram

4500-6000

Patna

4000-6000

Chennai

4500-6000

Jaipur

4000-6000

Ahmedabad

4500-6000

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, The Plasma Free Metanephrines Test detects adrenal tumors causing high blood pressure by measuring hormone levels in the blood, aiding early diagnosis and treatment. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Metanephrine - Wikipedia [1].
  • Plasma metanephrines: a novel and cost-effective test for ... - NIH [2].

 

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FAQ

What are Plasma Free Metanephrines?

Plasma Free Metanephrines (PFM) are blood tests used to measure levels of metanephrine and normetanephrine, which are breakdown products of the hormones adrenaline and noradrenaline produced by the adrenal glands. These tests help diagnose conditions like pheochromocytoma.

What are urine metanephrines?

Urine metanephrines are a group of chemical compounds that can be detected in a urine sample. They are breakdown products of catecholamines, which are hormones released by the adrenal glands in response to stress. The main urine metanephrines of interest are metanephrine and normetanephrine. Measuring these compounds in urine is a valuable diagnostic tool for assessing adrenal function and detecting certain medical conditions, especially those related to the adrenal medulla, such as pheochromocytoma.

Why are urine metanephrines measured?

Urine metanephrines are measured to evaluate adrenal gland function and to diagnose or rule out conditions like pheochromocytoma. Pheochromocytoma is a rare tumor that can cause excessive release of catecholamines, leading to high blood pressure, rapid heart rate, and other symptoms. Elevated levels of metanephrines in the urine may indicate the presence of this tumor. Additionally, urine metanephrine testing can help monitor the effectiveness of treatment for pheochromocytoma.

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