Globulins are primarily produced in the liver, although certain globulins are also produced by immune cells, such as lymphocytes and plasma cells. The liver is responsible for synthesizing and secreting a majority of the proteins found in the blood, including globulins. Once produced, globulins are released into the bloodstream, where they perform their respective functions, including immune response, transport, and blood clotting. However, it is important to note that different globulins have distinct sites of production within the body.