A concerning globulin level depends on various factors, including the reference range used by the laboratory, an individual's overall health, and the presence of other symptoms or medical conditions. Generally, significantly elevated or decreased globulin levels that fall outside the normal reference range (usually 2.3-3.5 g/dL) can be of concern. However, interpreting globulin levels requires evaluation in conjunction with other clinical findings and diagnostic tests to determine the underlying cause accurately. It is important to consult a healthcare professional for proper evaluation, interpretation, and appropriate management.