High levels of thyroxine, also known as hyperthyroidism, can lead to an overactive thyroid gland. This can result in symptoms such as weight loss, rapid heartbeat, tremors, irritability, anxiety, heat intolerance, increased sweating, fatigue, muscle weakness, and changes in menstrual patterns. If left untreated or unmanaged, high thyroxine levels can cause complications such as osteoporosis, heart problems, and eye-related issues. It is important to consult with a healthcare professional for accurate diagnosis and appropriate treatment if thyroxine levels are high.