When Bilirubin levels are high in the blood, it is typically a sign of a liver or gallbladder problem. Bilirubin is a yellow pigment produced during the breakdown of red blood cells. Elevated Bilirubin can cause jaundice, a condition characterized by yellowing of the skin and eyes. Other symptoms may include fatigue, abdominal pain, dark urine, and pale stools. High Bilirubin levels can indicate liver disease, hepatitis, cirrhosis, gallstones, or certain blood disorders, and further medical investigation is necessary to determine the underlying cause.