Calcitonin's direct effects on the brain are relatively limited. While calcitonin receptors have been identified in various brain regions, the precise functions and significance of these receptors in the central nervous system are not fully understood. However, some studies suggest that calcitonin may have neuroprotective properties and potentially modulate neurotransmitter release. Additionally, calcitonin receptors are found in brain regions associated with pain perception, and synthetic calcitonin has been used to manage pain in conditions such as bone metastases. Further research is needed to fully elucidate the extent and mechanisms of calcitonin's actions in the brain.