Several medications can increase Digoxin levels by affecting its metabolism or excretion. Some examples include verapamil, diltiazem, amiodarone, quinidine, spironolactone, propafenone, and certain antibiotics (such as clarithromycin and erythromycin). These drugs can inhibit the enzyme systems responsible for Digoxin clearance, leading to increased Digoxin concentrations in the bloodstream. Additionally, certain drug interactions can potentiate Digoxin's effects, increasing the risk of toxicity. It is crucial to inform your healthcare provider about all the medications, including prescription, over-the-counter, and herbal products, that you are taking to avoid potential interactions and ensure appropriate Digoxin dosage adjustments, if needed.