Low estradiol levels in women may suggest menopause, ovarian dysfunction, or anorexia nervosa. In men, low estradiol levels may be associated with certain hormonal disorders, testicular dysfunction, or excessive exercise and weight loss. Low estradiol levels can lead to symptoms like hot flashes, vaginal dryness, and bone density loss in women, while in men, it can contribute to fatigue, low libido, and mood disturbances. Identifying and addressing the underlying cause of low estradiol levels is crucial to manage associated symptoms and ensure overall health.