High Cortisol levels can manifest in various symptoms, including weight gain, especially around the abdomen, thinning of the skin, easy bruising, muscle weakness, mood swings, anxiety, irritability, sleep disturbances, high blood pressure, increased thirst and urination, and impaired immune function. These symptoms can vary depending on the underlying cause and individual factors. It's important to note that the presence of these symptoms alone does not necessarily indicate high Cortisol levels, as they can be caused by other factors as well. Proper medical evaluation and testing are required to determine Cortisol levels and diagnose any underlying conditions.