Common side effects of a prostate biopsy include mild pain or discomfort in the rectal or perineal area, temporary blood in the urine, stool, or semen, and mild urinary symptoms. These side effects typically subside within a few days to a week. It's essential to rest, follow post-biopsy care instructions, and contact your doctor if you experience severe pain, persistent bleeding, or signs of infection. Most men tolerate the procedure well, and the side effects are usually manageable.