High Progesterone levels in women are generally considered beneficial during pregnancy. However, outside of pregnancy, excessively high Progesterone levels can cause certain symptoms. Some possible symptoms of high Progesterone include breast tenderness, bloating, mood swings, fatigue, changes in appetite, and headaches. These symptoms may resemble premenstrual syndrome (PMS) symptoms, as Progesterone levels naturally increase during the luteal phase of the menstrual cycle. It is important to note that high Progesterone levels can be indicative of underlying conditions such as ovarian cysts or hormone-producing tumors. If symptoms persist or are severe, it is advisable to consult a healthcare professional for further evaluation and appropriate management.