Yes, globulin levels can be increased in liver disease. Liver diseases, such as cirrhosis, hepatitis, or liver cancer, can affect the liver's ability to produce proteins, including globulins. When the liver is damaged or not functioning properly, it may lead to a decrease in albumin production and an increase in globulin production, resulting in elevated globulin levels. However, it is important to note that elevated globulin levels alone are not specific to liver disease, and further diagnostic tests and evaluation are necessary to determine the underlying cause accurately. Consulting a healthcare professional is crucial for proper diagnosis and management.