The TB blood test, also known as interferon-gamma release assays (IGRAs), and the TB skin test (TST), such as the Mantoux Test, are two different methods used to detect tuberculosis (TB) infection. Both tests have their advantages and considerations. The TB blood test measures the immune response to TB-specific antigens in a blood sample, while the TST evaluates the delayed-type hypersensitivity reaction to purified protein derivative (PPD) injected into the skin. In terms of accuracy, both tests have their limitations. The TB blood test is less likely to be affected by prior Bacillus Calmette-Guérin (BCG) vaccination or exposure to non-tuberculous mycobacteria, which can lead to false-positive results in the TST. However, the TB blood test may have a higher cost, requires specialized laboratory facilities, and may be influenced by immune status. The choice of test depends on various factors, including local guidelines, availability, cost, and individual circumstances. It is crucial to consult with healthcare professionals familiar with TB management to determine the most appropriate test based on the specific situation. They can provide accurate interpretation of test results and guide further evaluation or treatment if necessary.