Low globulin levels alone may not directly cause fatigue or tiredness. However, if the underlying cause of low globulin, such as malnutrition, chronic disease, or autoimmune disorders, affects overall health and energy levels, fatigue can be a symptom. It is essential to address the specific cause of low globulin and any associated conditions to alleviate fatigue effectively. Consultation with a healthcare professional is crucial to determine the appropriate treatment and management plan.