The erythrocyte sedimentation rate (ESR) is a measure of how quickly red blood cells settle in a tube of blood. It is a non-specific marker of inflammation in the body. While globulins, particularly fibrinogen, can contribute to the ESR, the ESR is primarily influenced by other factors such as increased levels of acute-phase reactant proteins and changes in red blood cell characteristics. Elevated globulin levels alone may not directly correlate with an increased ESR. The ESR is typically influenced by multiple factors, and a thorough evaluation by a healthcare professional is necessary to interpret ESR results accurately.