While Progesterone can cause fluid retention, which may lead to temporary weight gain, it is unlikely to cause significant long-term weight gain on its own. Progesterone is involved in regulating various functions in the body, including metabolism and fluid balance. Changes in Progesterone levels, such as those experienced during the menstrual cycle or hormone replacement therapy, can result in water retention and bloating, leading to a temporary increase in weight. However, any weight gain associated with Progesterone is typically mild and reversible. Significant or persistent weight gain should be evaluated by a healthcare professional to determine the underlying cause, as it is likely attributed to other factors such as diet, lifestyle, or hormonal imbalances.