While the Mantoux Test, or tuberculin skin test (TST), is generally a reliable tool for detecting exposure to the tuberculosis (TB) bacteria, false-positive results can occur. Several factors can contribute to false positives, including previous vaccination with the Bacillus Calmette-Guérin (BCG) vaccine, which is used in many countries to prevent TB. The BCG vaccine can lead to a positive reaction on the Mantoux Test. Other mycobacterial infections or certain medical conditions, such as non-tuberculous mycobacterial infections or autoimmune diseases, can also cause false-positive results. Additionally, if the test is read incorrectly or if the person administering the test uses an incorrect technique, it can lead to inaccurate results. It is important to interpret the test results in conjunction with the person's medical history, risk factors, and clinical evaluation. If there is a concern about false-positive results, healthcare professionals may recommend further testing, such as chest X-rays or interferon-gamma release assays (IGRAs), to confirm the diagnosis and determine the appropriate next steps. The interpretation of TB test results should be done by healthcare professionals trained in TB management.