Several factors can influence the accuracy of a prostate biopsy, including the experience and skill of the urologist performing the procedure, the number and location of tissue samples obtained, and the quality of the samples. Additionally, the size and aggressiveness of the cancer, as well as the presence of benign conditions, can impact the biopsy's ability to detect cancer accurately. It's important to choose a skilled and experienced urologist, follow pre-procedure instructions, and discuss any concerns or questions about the biopsy's accuracy with your healthcare provider.